Last publications

Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4⁺ T Cells

Mélanie Lancien, Géraldine Bienvenu, Lucile Guéno, Emmanuel Merieau, Severine Remy, Amandine Even, Aurelie Moreau, Alice Molle, Cynthia Fourgeux, Flora Coulon, Gaelle Bériou, Laurence Bouchet-Delbos, Elise Chiffoleau, Peggy Kirstetter, Susan Chan, Steven Kerfoot, Saeed Abdu Rahiman, Veronica de Simone, Gianluca Matteoli, Gaëlle Boncompain ^{1, 2}, Franck Perez ^{1, 2}, Régis Josien ³ , Jérémie Poschmann, Maria Cristina Cuturi, ^{4, 5, 3} Cédric Louvet.
1 Institut Curie [Paris]
2 Biologie Cellulaire et Cancer
3 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
4 UN - Université de Nantes
5 CHU Nantes - Centre hospitalier universitaire de Nantes
J Immunol. 2021 Jul 7;ji2000498. doi: 10.4049/jimmunol.2000498.

The diversity of the plasmablast signature across species and experimental conditions : a meta-analysis

Alexis Grasseau^a, Marina Boudigou^a, Magalie Michée- Cospolite^a, Céline Delaloy^b, Olivier Mignen^a, Christophe Jamin^a,c, Divi Cornec^a,c, Jacques- Olivier Pers^a,c,
Laëtitia Le Pottier^a, Sophie Hillion^a,

^a UMR1227, LBAI, INSERM, Univ Brest,Brest, France
^b UMR U1236, INSERM, Etablissement Français du Sang (EFS) de Bretagne, Université de Rennes 1, Rennes, France
^c UMR1227, LBAI, INSERM, CHU de Brest, Univ Brest, Brest, France

Immunology. 2021 Sep;164(1):120-134. doi: 10.1111/imm.13344. Epub 2021 May 26

Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients

Brigitte Dréno^1,2,3,4,5, Amir Khammari^1,3,4,5, Agnès Fortun^3,4, Virginie Vignard^3,4,5,Soraya Saiagh², Tiffany Beauvais^3,4,5, Nicolas Jouand^4,6, Sylvain Bercegay², Sylvain Simon^3,4, François Lang^3,4 & Nathalie Labarrière^3,4,6

¹ Dermato‑Cancerology Department, CIC 1413, CHU Nantes, Nantes, France
² UTCG, CHU Nantes, Nantes, France
³ CRCINA, Inserm, Université de Nantes, 44000 Nantes, France
⁴ LabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France
⁵ CHU Nantes, Nantes, France
⁶ SFR Santé, CNRS, Inserm, Inserm UMS 016, CNRS UMS 3556, Université de Nantes, CHU Nantes, 44000 Nantes

Cancer Immunology, Immunotherapy (2021) - https://doi.org/10.1007/s00262-021-02961-0

An easy and reliable whole blood freezing method for flow cytometry immuno-phenotyping and functional analyses.

Cecile Braudeau ^{a, b}, Nina Salabert-Le Guen^{a, b},Chevreuil Justine ^{a, b}, Rimbert Marie^{a, b}, Jerome C. Martin^{a, b}, Regis Josien^{a, b}

^aLaboratoire d’Immunologie, CIMNA, LabEx IGO "Immunotherapy, Graft, Oncology", F-44000 Nantes, France
^b CHU Nantes, Nantes Université, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France

Cytometry Part B: Clinical Cytometry doi: 10.1002/cyto.b.21994

Cystathionine-gamma-lyase overexpression in T cells enhances anti- tumor effect independently of cysteine autonomy.

Melanie Lancien^1,2, Lucile Gueno^1,2, Sonia Salle^1,2, Emmanuel Merieau^1,2, Gaelle Beriou^1,2, Tuan H. Nguyen^1,2, Ahmed Abidi^1,3, Nahzli Dilek⁴, Pierre Solomon¹, Jeremie Poschmann¹, Olivier Michielin^4,5,6, Romain Vuillefroy de Silly⁵, Bernard Vanhove^1,7, Cedric Louvet¹

¹Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Université de Nantes, Nantes, France
²LabEx IGO “Immunotherapy, Graft,Oncology”, Nantes, France
³Faculty of Sciences, Tunis, University of Tunis El Manar, Tunis, Tunisia
⁴Molecular Modeling Group, SIB Swiss Institute for Bioinformatics, Lausanne, Switzerland
⁵The Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland
⁶Department of Oncology, University of Lausanne and Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

⁷Xenothera, Nantes, France

Cancer Science, Volume112, Issue5, May 2021, Pages 1723-1734 https://doi.org/10.1111/cas.14862

Anti-Tumor Efficacy of PD-L1 Targeted Alpha-Particle Therapy in a Human Melanoma Xenograft Model

Marisa Capitao¹, Justine Perrin¹, Sylvain Simon¹, Sébastien Gouard¹, Nicolas Chouin², Frank Bruchertseifer³, Alfred Morgenstern³, Latifa Rbah-Vidal¹, Michel Chérel⁴, Emmanuel Scotet¹, Nathalie Labarrière¹, Yannick Guilloux¹ and Joëlle Gaschet¹*

¹Université de Nantes, CNRS, Inserm, CRCINA, F-44000 Nantes, France
² Université de Nantes, CNRS, Inserm, Oniris, CRCINA, F-44000 Nantes, France
³ European Commission, Joint Research Centre, Directorate for Nuclear Safety and Security, G-76344 Karlsruhe, Germany
⁴ Université de Nantes, CNRS, Inserm, ICO Gauducheau, GIP Arronax, CRCINA, F-44000 Nantes, France

Cancers 2021, 13(6), 1256; https://doi.org/10.3390/cancers13061256

Mechanisms of autoimmune hepatitis

Cardon, Anaïs; Conchon, Sophie∗; Renand, Amédée

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France

Current Opinion in Gastroenterology: March 2021 - Volume 37 - Issue 2 - p 79-85
doi: 10.1097/MOG.0000000000000704

Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes

L Marotte^a,^b*, M Capitao^a,^b*, C Deleinea,^b, T Beauvais^b,c, G Cadiou^a,^b, J. Perrin^a,b, M Chérel^d,e,f, E Scotet^a,b, Y Guilloux^a,b, F Bruchertseifer^g, A Morgenstern^g, A Jarry^a,b, J. Gaschet^a,b*, and N Labarriere^a,b*
^aUniversité De Nantes, CNRS, INSERM, CRCINA, Nantes, France;
^bLabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France;
^cUniversité De Nantes, CNRS, INSERM, CRCINA, CHU of Nantes, Nantes, France;
^dUniversité De Nantes, CNRS, INSERM, CRCINA, ICO Gauducheau, Nantes, France;
^eLabEx IRON “Innovative Radiopharmaceuticals in Oncology and Neurology”, Nantes, France;
^fGIP Arronax, Saint-Herblain, France; ^gEuropean Commission, Joint Research Centre (JRC), Karlsruhe, Germany

OncoImmunology, 10:1, 1940676, DOI: 10.1080/2162402X.2021.1940676

Mis à jour le 13 October 2021.